No. 07 · Nurse-led

Polynucleotides
in Whitley Bay.

DNA-based bio-stimulation. Under-eyes. Texture. Long-term skin quality.

St Mary’s Lighthouse at Whitley Bay, near Refined Medical Aesthetics in Seaton Delaval.
Duration
45 mins
Downtime
Minimal
From
£185
The approach

What to expect.

Polynucleotides are regenerative injections from salmon DNA. They wake up your fibroblasts. Those cells then make collagen and elastin. Excellent for under-eye hollowing, skin laxity and long-term quality.

Areas we treat: Under-eyes · Texture · Laxity

Polynucleotide treatment at Refined Medical Aesthetics, Seaton Delaval near Whitley Bay.
How it works

Three steps.

01
Consultation
A proper chat first. Your goals. Your history. Suitability. No needle today.
02
Treatment
Done by me. Prescription-only products. Sourced through licensed UK pharmacies.
03
Two-week review
Included with every appointment. Small tweaks at this review? On the house.
Pricing

What it costs.

Polynucleotides are priced by area. Most clients start with eyes (the area most clinics won’t put filler in). Then they build to face if they want skin-quality improvement everywhere.

Treatment Per session
Eyes (under-eye, tear-trough region). 45 mins £185 Book
Face. 45 mins £210 Book
Face + neck. 60 mins £250 Book

Best results come from three sessions, three weeks apart. We agree the protocol at consultation. Free 30-minute consultation if you’re new.

The science, plainly

What they actually do.

Polynucleotides are short, purified DNA fragments. Usually from salmon roe. Highly purified. No allergenic protein. They’re a regenerative injectable. Not a filler. They don’t add volume or change your features.

I inject them into the layer just below your skin. They switch on the cells (fibroblasts) that make collagen, elastin and hyaluronic acid. They wake up cells that have been sleeping. The result builds slowly. Skin gets thicker, denser, better quality. Lines soften because the skin is healthier. Not because something has been filled in.

Polynucleotides shine in the under-eye. The skin there is the thinnest on the face. The area most prone to dark circles, hollowness and crepiness as we age. Filler under the eye is risky. It’s a tight space. Blood vessels are close. Then there’s the dreaded Tyndall effect (a bluish tint when filler sits too superficially). Polynucleotides give us a way to improve under-eye quality without those risks.

Other places they earn their keep: scarred skin, sun-damaged skin, skin that’s lost density after weight loss or pregnancy. And the neck and décolleté where filler isn’t usually right.

Suitability

Who this is for.

Polynucleotides suit you if you:

I’ll recommend something else if you:

On the day

From door to done.

Numbing cream goes on for 15 minutes. Especially important for the under-eye area. The skin there is more sensitive. While we wait, we run through the plan again. You’ll know exactly what we’re doing.

For under-eye, I work in small precise points just below the lash line. For face, micro-droplets across cheeks and jawline. For neck, a longer linear technique. Whole appointment is around 45 minutes including numbing.

Bruising is common in the under-eye area. The skin is thin and vascular. Plan for visible bruising for up to a week. Mild swelling for 24 hours. The result builds across 3 to 12 weeks. You usually notice the change after the second session.

Aftercare

The first 48 hours.

Risks, openly

What I tell everyone.

Common: bruising. Especially under-eye. Can last 7 to 10 days. Small papules at injection points (settle within 24 to 48 hours). Mild redness. Occasional brief tenderness.

Rare: allergic reaction. The product is highly purified. Allergy testing isn’t usually required. Infection at injection points (good aftercare prevents this).

NMC-registered. Fully indemnified. On the regulators’ lists at NMC, Save Face and JCCP.

Common questions

Good to know.

Are polynucleotides safe?
Yes. Polynucleotides are highly purified biological material. Excellent safety profile. Allergy testing isn’t usually required. Got a known fish allergy? Tell me at consultation and we’ll talk it through.
Are they made from salmon?
The DNA fragments come from salmon roe. They’re highly purified to remove all allergenic protein. What’s left is the genetic material itself. Not anything that would trigger a fish allergy in most people.
Will I see under-eye improvement?
Most clients see improvement in dark circles, skin thickness and crepiness by session 2 of a 3-session course. The change is gradual. It builds across 3 to 12 weeks.
How is this different from skin boosters?
Skin boosters (Profhilo, Seventy Hyal etc.) are mainly hydration. Polynucleotides are regeneration. They actively switch on the cells that make collagen and elastin. The two go well together. Sometimes we alternate them.
How is this different from tear-trough filler?
Tear-trough filler adds volume to fill the hollow under the eye. Polynucleotides improve the skin quality of the area without adding volume. They’re often safer if your under-eye issue is skin quality rather than volume loss. Sometimes we sequence both.
How many sessions do I need?
Three sessions, three weeks apart, is the standard protocol for proper results. After that, a maintenance session every 6 to 12 months keeps the improvement going.
How long do results last?
After a 3-session course, results usually hold for 6 to 12 months. The treatment regenerates rather than fills. The improvement is to your own tissue. It doesn’t simply “wear off” the way filler does. Maintenance keeps the regeneration going.
Will I bruise under my eyes?
Often, yes. The under-eye skin is thin and vascular. Plan for visible bruising for 7 to 10 days. Arnica gel and tablets help. Concealer covers it after day 2.
Does it hurt?
Numbing cream first. Especially important under the eye. You feel pin-prick pressure. Not sharp pain. The under-eye area is more sensitive than face injections.
Can I have it if I’m pregnant or breastfeeding?
No. We wait. The principle for non-essential cosmetic treatment in pregnancy is to put it on hold.
Ready?

Book your polynucleotides.

Choose your option and pick a time — booked online in under a minute.

Related treatments

You might also explore.

Also consider
Skin boosters
Profhilo and Seventy Hyal for skin quality.
Also consider
Microneedling
Collagen induction for texture and tone.
Also consider
Book a consultation
Free, 30 minutes. No pressure to book a treatment.
Further reading

From the journal.

Polynucleotides, explained
Areas we serve

Across the North East.

Clients travel from across the North East for polynucleotides at Refined. Pick your town below for the drive, parking and local questions.

Tynemouth · 4 miles
Polynucleotides in Tynemouth
12-min drive via the A1058 Coast Road.
Cramlington · 4 miles
Polynucleotides in Cramlington
10-min drive via the A189.
Newcastle upon Tyne · 8 miles
Polynucleotides in Newcastle
25-min drive heading north on the A189.
Blyth · 3 miles
Polynucleotides in Blyth
9-min drive via the A193.
Morpeth · 12 miles
Polynucleotides in Morpeth
22-min drive via the A192.
North Shields · 5 miles
Polynucleotides in North Shields
15-min drive via the A1058 Coast Road.
Gosforth · 8 miles
Polynucleotides in Gosforth
20-min drive via A191 then A189.
Jesmond · 9 miles
Polynucleotides in Jesmond
22-min drive via A1058 or A189.
Darras Hall · 14 miles
Polynucleotides in Darras Hall
28-min drive via A189 then A696.
Ponteland · 12 miles
Polynucleotides in Ponteland
25-min drive via A696 then A189.

Last updated: 7 May 2026