No. 07 · Nurse-led

Poly-
nucleotides.

DNA-based bio-stimulation for under-eyes, texture and long-term skin quality.

Duration

45 mins

Downtime

Minimal

From

£185

The approach

What to expect.

Polynucleotides are regenerative injections derived from salmon DNA — they stimulate your own fibroblasts to produce collagen and elastin. Excellent for under-eye hollowing, skin laxity and long-term quality.

Areas we treat: Under-eyes · Texture · Laxity

How it works

Three steps.

Consultation

We start with a conversation about your goals, history and suitability — never a needle.

Treatment

Delivered by Rachel with medical precision, using prescription-only products sourced through licensed pharmacies.

Two-week review

Included with every appointment. Small tweaks at this review are on the house.

Pricing

What it costs.

Polynucleotides are priced by area. Most clients start with eyes (the area most clinics won’t put filler in), then build to face if they want skin-quality improvement across the whole face.

Treatment	Per session
Eyes (under-eye, tear-trough region) — 45 mins	£185
Face — 45 mins	£210
Face + neck — 60 mins	£250

Best results are a course of three sessions, three weeks apart. We agree the protocol at consultation. Free 30-minute consultation if you’re new.

The science, plainly

What they actually do.

Polynucleotides are short, purified DNA fragments — usually derived from salmon roe (highly purified, no allergenic protein). They’re a regenerative injectable, not a filler. They don’t add volume or change your features.

When I inject them into the layer just below your skin, they switch on the cells (fibroblasts) that produce collagen, elastin and hyaluronic acid. Effectively, they wake up the cells that have been sleeping. The result builds slowly: skin gets thicker, denser, better quality. Lines soften because the skin is healthier, not because something has been filled in.

The area where polynucleotides shine is the under-eye. The skin there is the thinnest on the face and the area most prone to dark circles, hollowness and crepiness as we age. Filler under the eye is risky — it’s a tight space with nearby blood vessels and the dreaded Tyndall effect (a bluish tint when filler sits too superficially). Polynucleotides give us a way to improve under-eye quality without those risks.

Other places they earn their keep: scarred skin, sun-damaged skin, skin that’s lost density after weight loss or pregnancy, and the neck/décolleté where filler isn’t typically appropriate.

Suitability

Who this is for.

Polynucleotides suit you if you:

Have under-eye hollowness, darkness or crepiness and want improvement without filler
Want skin quality improvement that builds gradually rather than instantly
Have sun-damaged or scarred skin that needs cellular-level regeneration
Are willing to commit to a course of 3 sessions for proper results
Are 18+, not pregnant or breastfeeding

I’ll recommend something else if you:

Want immediate volume restoration — that’s filler, not polynucleotides
Have a fish allergy (rare with this product but worth checking)
Are pregnant or breastfeeding
Have an active autoimmune flare

On the day

From door to done.

Numbing cream goes on for 15 minutes — especially important for the under-eye area where the skin is more sensitive. While we wait, we go over the protocol again so you know exactly what we’re doing.

For under-eye, I work in small precise points just below the lash line. For face, micro-droplets across the cheeks and jawline. For neck, longer linear technique. The whole appointment is around 45 minutes including numbing.

Bruising is common in the under-eye area — the skin is thin and vascular. Plan for visible bruising for up to a week. Mild swelling for 24 hours. The result builds across 3-12 weeks; you’ll often notice the change after the second session.

Aftercare

The first 48 hours.

Cool compresses (not ice directly) for the first few hours
Don’t rub or massage the treated area for 24 hours
No alcohol for 24 hours
No strenuous exercise or saunas for 24 hours
No facials, peels, microneedling or laser for 14 days
SPF on the area daily — sun damage undoes the work you’ve invested in
Sleep elevated the first night to reduce under-eye swelling
Bruising can take 7-10 days to fully resolve — arnica gel helps

Risks, openly

What I tell everyone.

Common: bruising (especially under-eye, can last 7-10 days), small papules at injection points (settle within 24-48 hours), mild redness, occasional brief tenderness.

Rare: allergic reaction (the product is highly purified and allergy testing isn’t typically required), infection at injection points (good aftercare prevents this).

NMC-registered, fully indemnified, and on the regulators’ lists at NMC, Save Face and JCCP.

Common questions

Good to know.

Are polynucleotides safe?

Yes — polynucleotides are highly purified biological material with an excellent safety profile. Allergy testing isn’t typically required, but tell me at consultation if you have a known fish allergy and we’ll discuss.

Are they made from salmon?

The DNA fragments are typically derived from salmon roe, then highly purified to remove all allergenic protein. What remains is the genetic material itself, not anything that would trigger a fish allergy in most people.

Will I see under-eye improvement?

Most clients see improvement in dark circles, skin thickness and crepiness by session 2 of a 3-session course. The change is gradual — it builds across 3-12 weeks.

How is this different from skin boosters?

Skin boosters (Profhilo, Seventy Hyal etc.) are mainly hydration. Polynucleotides are regeneration — they actively switch on the cells that make collagen and elastin. The two complement each other and we sometimes alternate them.

How is this different from tear-trough filler?

Tear-trough filler adds volume to fill the hollow under the eye. Polynucleotides improve the skin quality of the area without adding volume. They’re often safer for clients whose under-eye issue is skin quality rather than volume loss. Sometimes we sequence both.

How many sessions do I need?

A course of three sessions, three weeks apart, is the standard protocol for proper results. After that, a maintenance session every 6-12 months keeps the improvement going.

How long do results last?

After a 3-session course, results typically hold for 6-12 months. Because the treatment regenerates rather than fills, the improvement is to your own tissue — it doesn’t simply “wear off” the way filler does. Maintenance keeps stimulating regeneration.

Will I bruise under my eyes?

Often, yes — the under-eye skin is thin and vascular. Plan for visible bruising for 7-10 days. Arnica gel and tablets help. Concealer covers it after day 2.

Does it hurt?

Numbing cream first — especially important under the eye. You’ll feel pin-prick pressure rather than sharp pain. The under-eye area is more sensitive than face injections.

Can I have it if I’m pregnant or breastfeeding?

No — we’d wait. The principle of treating non-essential cosmetic procedures during pregnancy is to defer.

Ready?