No. 07 · Nurse-led

Polynucleotides
in Whitley Bay.

Watch the 3 short videosFrom consultation to aftercare. No sound, words on screen.

Polynucleotides (regenerative skin treatment) is a consultation led treatment tailored to your goals, medical history and suitability. It is available at Refined Medical Aesthetics, our nurse led clinic on Double Row, Seaton Delaval, Northumberland, near Whitley Bay, NE25 0PP. Pricing, suitability and a careful, personalised plan are discussed before treatment.

Nurse led clinic. Careful, documented treatment.

Real clients, real clinic

Better skin, built slowly.

45 minute visit
Numbing cream first
A course of 3 sessions
Change builds over 3 to 12 weeks

Client comparison photograph 10, published by Refined Medical Aesthetics with permission — Client photo, shared with permission

Rachel Storey treating a client at Refined Medical Aesthetics — In clinic with me

Client comparison photograph 33, published by Refined Medical Aesthetics with permission — Client photo, shared with permission

Client comparison photograph 02, published by Refined Medical Aesthetics with permission — Client photo, shared with permission

Inside Refined Medical Aesthetics in Seaton Delaval — My clinic in Seaton Delaval

Client comparison photograph 18, published by Refined Medical Aesthetics with permission — Client photo, shared with permission

Client comparison photograph 20, published by Refined Medical Aesthetics with permission — Client photo, shared with permission

Photos from my client gallery, shared with permission. Results vary from person to person. See the full gallery

Polynucleotides at a glance

Who it may help: Adults with hollow, dark or crepey skin under the eyes, or skin that has lost quality, who want a gradual change without filler.
What happens: Numbing cream for 15 minutes, then small injections. The visit takes about 45 minutes. Most people need 3 sessions, three weeks apart.
Downtime: Bruising under the eyes is common and can last 7 to 10 days. Mild swelling for 24 hours.
Price: Per session: eyes £185, face £210, face and neck £250.
Book: Your first 30 minute consultation is free if you are new. See prices and payment options or book a time.

Results vary from person to person.

Short videos

Watch before you book.

Each video is about a minute long and walks through one treatment. They have no sound. The words are shown on screen and written out under each one.

Video

Polynucleotides for the under eyes

A short video about polynucleotides for the under eye area, from your consultation to aftercare. It has no sound. The words are written out below.

Some images in this video are AI generated for illustration. They are not clients. Results vary from person to person.

What the video says

Under eye polynucleotides Tired under eyes that concealer won’t fix? Let me talk you through polynucleotides.
Why the under eye Your thinnest, most delicate skin Crepey fine lines A hollow, tired look Shadows that show through
What they are What are polynucleotides? An injectable made from purified DNA fragments that may help your skin repair and renew. Not a filler, so no added volume.
What I use Plinest One by Mastelli Polynucleotides from the Italian brand that first developed them.
Your appointment What to expect Numbing cream first About 45 minutes, done by me
The treatment Lots of tiny injections Placed carefully into the thin skin under the eye.
Completely normal Tiny marks afterwards Any tiny marks are usually hard to notice. They settle within 24 to 48 hours.
Downtime Usually minimal downtime Some puffiness or bruising for a few days No makeup on the area for 24 hours
Results Results build slowly Most people need a course of 3, a few weeks apart. Results vary from person to person.
Not sure it’s right for you? Polynucleotides, under eyes: £185 New to me? Your consultation is free. Seaton Delaval, near Whitley Bay. Book online or message me

Video

Polynucleotides for the face

A short video about polynucleotides for the face, from your consultation to aftercare. It has no sound. The words are written out below.

Some images in this video are AI generated for illustration. They are not clients. Results vary from person to person.

What the video says

polynucleotides, face Skin looking tired lately?
why it happens Less collagen, thinner skin With age, skin makes less collagen and elastin. Cheeks go a bit crepey and fine lines start to show.
what I use Plinest One Purified DNA fragments from salmon roe, made by Mastelli in Italy. It adds no volume, so you still look like you.
Waking up sleepy cells DNA fragments go in just under the skin Your fibroblasts switch back on Fresh collagen and elastin follow
before we start Your skin, looked at properly New to me? The 30 minute consultation is free. Goals and history first, then a plan.
Tiny droplets, spread evenly Numbing cream on for 15 minutes Micro droplets across cheeks and jawline About 45 minutes, door to done
Mostly pin prick pressure The numbing cream does most of the work, so it shouldn't feel sharp.
straight after Tiny marks for a day or two They're usually hard to notice and settle within 24 to 48 hours.
Then go gently first 24 hours Hands off your face No alcohol, gym or sauna for two weeks No facials, peels or laser SPF every morning
Denser, healthier skin It may help texture and fine lines, building slowly over 3 to 12 weeks. Results vary.
Three sessions, three weeks apart today week 3 week 6 later You'll usually notice it after the second Then a top up every 6 to 12 months
Ready when you are Polynucleotides, face: £210 New to me? Your consultation is free. Seaton Delaval, near Whitley Bay. Book online or message me

Video

Polynucleotides for the face and neck

A short video about polynucleotides for the face and neck, from your consultation to aftercare. It has no sound. The words are written out below.

Some images in this video are AI generated for illustration. They are not clients. Results vary from person to person.

What the video says

Noticing it on your neck?
Why it happens Thinner skin, finer lines As we age, skin makes less collagen and elastin. It loses its spring, and the neck often shows it first.
What I use Plinest One Purified DNA fragments from salmon, made by Mastelli. It isn't a filler, so your features stay your own.
A wake up call for your cells Fragments go in under the skin Your fibroblasts switch on Fresh collagen and elastin
A proper chat first Your goals, your medical history and whether it suits you. Got a fish allergy? Tell me.
Face and neck Tiny droplets across cheeks and jaw Fine threads along the neck
On the day Numbing cream, then a fine needle The cream goes on for about 15 minutes. Face and neck together take around an hour.
Straight after Tiny marks for a day or two They usually settle in 24 to 48 hours. Some redness or a small bruise can happen too.
At home Go easy on it this week No makeup for 12 to 24 hours. Skip saunas, hard workouts and alcohol for a day or two, leave out retinoids and acids for 3 to 5 days, and wear SPF 30 every day.
Results vary Better skin, in its own time Skin quality may improve over 3 to 12 weeks. Most people notice it after the second session.
Best as a course Three sessions about three weeks apart Then it builds over the following weeks A top up every 6 to 12 months
Curious if it suits you? Polynucleotides, face and neck: £250 New to me? Your consultation is free. Seaton Delaval, near Whitley Bay. Book online or message me

How it works

From door to done.

ConsultationNo needles. We talk about your skin and your health, and I check the treatment is right for you.
Numbing cream15 minutes, which matters most under the eyes. We go over the plan again so you know what we’re doing.
TreatmentSmall points just below the lash line, tiny droplets across cheeks and jawline, or short lines on the neck. About 45 minutes in all.
The first weekUnder eye bruising is common and may show for up to a week. Mild swelling for 24 hours.
Your courseUsually 3 sessions. The change builds over 3 to 12 weeks, and most people notice it after the second.

Pricing

What it costs.

Polynucleotides are priced by area. Many people start with the under eye area. Some then go on to treat the face for better skin quality.

Treatment	Per session
Eyes (under-eye, tear-trough region). 45 minsRegenerative treatment for under-eye skin quality.	£185	Pay deposit Pay in full Pay with KlarnaFor Klarna, choose Pay by card at checkout, then select Klarna from the dropdown.
Face. 45 minswe will assess suitability and keep the result subtle and natural.	£210	Pay deposit Pay in full Pay with KlarnaFor Klarna, choose Pay by card at checkout, then select Klarna from the dropdown.
Face + neck. 60 minsRegenerative skin quality support for face and neck.	£250	Pay deposit Pay in full Pay with KlarnaFor Klarna, choose Pay by card at checkout, then select Klarna from the dropdown.

Most people get the best results from three sessions, three weeks apart. We agree your plan at your consultation. If you are new, your first 30 minute consultation is free.

Before you book

The honest details.

What they are

Purified DNA fragments, usually from salmon, with the protein that can cause allergies removed. They aren’t a filler and don’t add volume or change your features.
How they may help. Placed just under the skin, they may help switch on the cells that make collagen, elastin and hyaluronic acid. Skin may become thicker and healthier, and fine lines may look softer.
Under the eyes. The thinnest skin on the face, where dark circles, hollows and crepey skin show first. Filler there carries more risk (tight space, close blood vessels, a possible blue tint). Polynucleotides may help without those risks.
Elsewhere. Scarred or sun damaged skin, skin that has lost firmness after weight loss or pregnancy, and the neck and chest.

Is it for me?

Your under eyes look hollow, dark or crepey and you’d rather avoid filler.
You want skin quality to improve gradually rather than instantly.
You have sun damaged or scarred skin.
You’re happy to commit to a course of 3 sessions.
You’re 18 or over, and not pregnant or breastfeeding.

I’ll recommend something else if you:

Want instant volume. That’s filler, not polynucleotides.
Have a fish allergy. Rare with this product, but I check.
Are pregnant or breastfeeding.
Have an active autoimmune flare.

Aftercare

Cool compresses, not ice directly, for the first few hours.
Don’t rub or massage the area for 24 hours.
No alcohol, hard exercise or saunas for 24 hours.
No facials, peels, microneedling or laser for 14 days.
SPF on the area every day. Sun damage undoes the work.
Sleep propped up the first night to reduce under eye swelling.
Bruising can take 7 to 10 days to clear. Arnica gel helps.

Risks

Common: bruising, mostly under the eyes, for 7 to 10 days. Small bumps that settle within 24 to 48 hours. Mild redness and short lived tenderness.
Rare: an allergic reaction. The product is highly purified, so an allergy test isn’t usually needed. Infection at the injection points is also rare, and good aftercare helps prevent it.

I’m registered with the NMC.

Common questions

Good to know.

Are polynucleotides safe?

Yes. Polynucleotides are highly purified biological material. Excellent safety profile. Allergy testing isn’t usually required. Got a known fish allergy? Tell me at consultation and we’ll talk it through.

Are they made from salmon?

The DNA fragments come from salmon roe. They’re highly purified to remove all allergenic protein. What’s left is the genetic material itself. Not anything that would trigger a fish allergy in most people.

Will I see under-eye improvement?

Most clients see improvement in dark circles, skin thickness and crepiness by session 2 of a 3-session course. The change is gradual. It builds across 3 to 12 weeks.

How is this different from skin boosters?

Skin boosters (Profhilo, Seventy Hyal etc.) are mainly hydration. Polynucleotides are regeneration. They actively switch on the cells that make collagen and elastin. The two go well together. Sometimes we alternate them.

How is this different from tear-trough filler?

Tear-trough filler adds volume to fill the hollow under the eye. Polynucleotides improve the skin quality of the area without adding volume. They’re often safer if your under-eye issue is skin quality rather than volume loss. Sometimes we sequence both. Read about tear trough filler.

How many sessions do I need?

Three sessions, three weeks apart, is the standard protocol for proper results. After that, a maintenance session every 6 to 12 months keeps the improvement going.

How long do results last?

After a 3-session course, results usually hold for 6 to 12 months. The treatment regenerates rather than fills. The improvement is to your own tissue. It doesn’t simply “wear off” the way filler does. Maintenance keeps the regeneration going.

Will I bruise under my eyes?

Often, yes. The under-eye skin is thin and vascular. Plan for visible bruising for 7 to 10 days. Arnica gel and tablets help. Concealer covers it after day 2.

Does it hurt?

Numbing cream first. Especially important under the eye. You feel pin-prick pressure. Not sharp pain. The under-eye area is more sensitive than face injections.

Can I have it if I’m pregnant or breastfeeding?

No. We wait. The principle for non-essential cosmetic treatment in pregnancy is to put it on hold.

Ready?